Hearing loss (HL) is a common sensory disorder in humans with high genetic heterogeneity. To date, over 145 loci have been\nidentified to cause nonsyndromic deafness. Furthermore, there are countless families unsuitable for the conventional linkage\nanalysis. In the present study, we used a custom capture panel (MiamiOtoGenes) to target sequence 180 deafness-associated genes\nin 5 GJB2 negative deaf probands with autosomal recessive nonsyndromic HL from Iran. In these 5 families, we detected one\nreported and six novel mutations in 5 different deafness autosomal recessive (DFNB) genes (TRIOBP, LHFPL5, CDH23, PCDH15,\nand MYO7A).The customcapture panel in our study provided an efficient and comprehensive diagnosis for known deafness genes\nin small families.
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